Transcriptional pro¢lingofFrancisella tularensis infectedperipheral bloodmononuclear cells: a predictive tool for tularemia
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چکیده
Transcriptional pro¢lingofFrancisella tularensis infectedperipheral bloodmononuclear cells: a predictive tool for tularemia Chrysanthi Paranavitana, Phillip R. Pittman, Mahendran Velauthapillai, Elzbieta Zelazowska & Luis DaSilva Department of Bacterial and Rickettsial Diseases, Walter Reed Army Institute of Research, Silver Spring, MD, USA; Division of Medicine, US Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, MD, USA; Department of Computer Sciences, Georgetown University, Washington, DC, USA; and Center for Aerobiological Sciences, USAMRIID, Frederick, MD, USA
منابع مشابه
Transcriptional profiling of Francisella tularensis infected peripheral blood mononuclear cells: a predictive tool for tularemia.
In this study, we analyzed temporal gene expression patterns in human peripheral blood mononuclear cells (PBMCs) infected with the Francisella tularensis live vaccine strain from 1 to 24 h utilizing a whole human Affymetrix gene chip. We found that a considerable number of induced genes had similar expression patterns and functions as reported previously for gene expression profiling in patient...
متن کاملRespiratory Tularemia: Francisella Tularensis and Microarray Probe Designing
BACKGROUND Francisella tularensis (F. tularensis) is the etiological microorganism for tularemia. There are different forms of tularemia such as respiratory tularemia. Respiratory tularemia is the most severe form of tularemia with a high rate of mortality; if not treated. Therefore, traditional microbiological tools and Polymerase Chain Reaction (PCR) are not useful for a rapid, reliable, accu...
متن کاملGeneration of a Convalescent Model of Virulent Francisella tularensis Infection for Assessment of Host Requirements for Survival of Tularemia
Francisella tularensis is a facultative intracellular bacterium and the causative agent of tularemia. Development of novel vaccines and therapeutics for tularemia has been hampered by the lack of understanding of which immune components are required to survive infection. Defining these requirements for protection against virulent F. tularensis, such as strain SchuS4, has been difficult since ex...
متن کاملDevelopment of a novel Francisella tularensis Live Vaccine Strain expressing ovalbumin provides insight into antigen-specific CD8+ T cell responses
Progress towards a safe and effective vaccine for the prevention of tularemia has been hindered by a lack of knowledge regarding the correlates of protective adaptive immunity and a lack of tools to generate this knowledge. CD8+ T cells are essential for protective immunity against virulent strains of Francisella tularensis, but to-date, it has not been possible to study these cells in an antig...
متن کاملVirulent Type A Francisella tularensis actively suppresses cytokine responses in human monocytes
BACKGROUND Human monocyte inflammatory responses differ between virulent and attenuated Francisella infection. RESULTS A mixed infection model showed that the virulent F. tularensis Schu S4 can attenuate inflammatory cytokine responses to the less virulent F. novicida in human monocytes. CONCLUSION F. tularensis dampens inflammatory response by an active process. SIGNIFICANCE This suppres...
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تاریخ انتشار 2008